ncRNA name | SDCBP siRNA |
ncRNA Category | siRNA |
Disease name | uveal melanoma (UM) |
Species | Homo sapiens |
Tissues/Cell_line | human UB cell lines Mel 270 and 92.1 |
Methods | microarray, RT-PCR, immunostaining, immunoblot, FACS analysis, siRNA transfection, immunohistochemistry, xenograft |
Expression pattern | associated |
Functional description | The inhibition of SDCBP expression by siRNA impaired the ability of uveal melanoma cells to migrate in a wound-healing assay. Moreover, silencing of SDCBP in mda-9/syntenin-high uveal melanoma cells inhibited the hepatocyte growth factor (HGF)-triggered invasion of matrigel membranes and inhibited the activation of FAK, AKT and Src. |
PubMed ID | 22267972 |
Year | 2012 |
Title | Mda-9/syntenin is expressed in uveal melanoma and correlates with metastatic progression. |
Drug-related ncRNA | NO |
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